In order to further standardize and guide the clinical trials of drugs for the treatment of acute non-variceal upper gastrointestinal bleeding and provide technical specifications that can be referred to, the Center for Drug Evaluation has organized to develop the Technical Guidance for Clinical Trials of Drugs for the Treatment of Acute Non-Variceal Upper Gastrointestinal Bleeding under the deployment of the National Medical Products Administration, which was issued and implemented on August 6, 2021 upon the review and approval of the NMPA.