To implement the Regulations on Supervision and Administration of Cosmetics, further regulate the administration of cosmetic ingredients, and encourage innovation in raw materials, the following matters concerning the Inventory of Existing Cosmetic Ingredients (hereinafter referred to as the Inventory) are hereby announced:

I. In accordance with the Regulations on Supervision and Administration of Cosmetics, cosmetic ingredients that have been registered or filed, and have completed a three-year safety monitoring period without any safety concerns, should be included in the Inventory. To facilitate ingredient management, the NMPA has divided the Inventory into two sublists: List I and List II. The Inventory issued by the NMPA in 2021 has been partially revised and refined, and will now be managed as List I of the Inventory, while new cosmetic ingredients that have completed the safety monitoring period will be included in the Inventory and managed as List II of the Inventory.

II. List I of the Inventory is based on the IECIC issued in 2021, with the following adjustments: the "Maximum Historical Usage Level" item has been removed; the Chinese, INCI, and English names of relevant ingredients have been standardized; and ingredient remarks have been revised in accordance with the Technical Specification for the Safety of Cosmetics. List II of the Inventory includes two new cosmetic ingredients—N-Acetylneuraminic Acid and β-Alanyl Hydroxyprolyl Diaminobutyric Acid Benzylamide—which have been filed, have completed the three-year safety monitoring period, and have been assessed as compliant with applicable regulatory requirements.

III. The NMPA has established a dynamic adjustment mechanism for the Inventory. The Inventory will be continuously updated and improved based on scientific research progress, industry development, and regulatory practices. Adjustments may include additions, refinements, and corrections.

IV. Effective immediately, the NMPA will no longer issue the Inventory in the form of official announcements. All future updates to the Inventory and related adjustment notes will be proactively disclosed on the official NMPA website. The query channel is the "Cosmetics → Cosmetic Query → Inventory of Existing Cosmetic Ingredients" on the official website of NMPA.

It is hereby announced.

National Medical Products Administration

June 23, 2025